PON1, paraoxonase 1, 5444

N. diseases: 496; N. variants: 29
Source: ALL
Variant Gene Disease Risk Allele Score vda Association Type Original DB Sentence supporting the association PMID PMID Year
dbSNP: rs3917539
rs3917539
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2985280
Disease:
Blood Protein Measurement 		TAA 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs1157745
rs1157745
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2985280
Disease:
Blood Protein Measurement 		T 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs3917532
rs3917532
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2985280
Disease:
Blood Protein Measurement 		T 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs757158
rs757158
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0201899
Disease:
Aspartate aminotransferase measurement 		T 0.700 GeneticVariation GWASCAT Connecting genetic risk to disease end points through the human blood plasma proteome. 28240269 2017
dbSNP: rs854560
rs854560
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2674665
Disease:
MICROVASCULAR COMPLICATIONS OF DIABETES, SUSCEPTIBILITY TO, 5 (finding) 		T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs854560
rs854560
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C1840169
Disease:
CORONARY ARTERY DISEASE, SUSCEPTIBILITY TO 		T 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs854560
rs854560
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C1827841
Disease:
Enzyme activity finding 		T 0.700 GeneticVariation CLINVAR
dbSNP: rs2057681
rs2057681
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2257843
Disease:
paraoxonase activity 		G 0.700 GeneticVariation GWASDB Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. 22982463 2012
dbSNP: rs2057681
rs2057681
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0523465
Disease:
Serum albumin measurement 		G 0.700 GeneticVariation GWASDB A genome-wide assessment of variability in human serum metabolism. 23281178 2013
dbSNP: rs3917545
rs3917545
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs3917549
rs3917549
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C1827841
Disease:
Enzyme activity finding 		C 0.700 GeneticVariation CLINVAR
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C1840169
Disease:
CORONARY ARTERY DISEASE, SUSCEPTIBILITY TO 		C 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C3149706
Disease:
CORONARY ARTERY SPASM 2, SUSCEPTIBILITY TO 		C 0.700 SusceptibilityMutation CLINVAR
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2985280
Disease:
Blood Protein Measurement 		C 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs854572
rs854572
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2257843
Disease:
paraoxonase activity 		C 0.700 GeneticVariation GWASDB Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk. 22982463 2012
dbSNP: rs705379
rs705379
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2985280
Disease:
Blood Protein Measurement 		A 0.700 GeneticVariation GWASCAT Genomic atlas of the human plasma proteome. 29875488 2018
dbSNP: rs11292716
rs11292716
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0201899
Disease:
Aspartate aminotransferase measurement 		0.700 GeneticVariation GWASCAT Connecting genetic risk to disease end points through the human blood plasma proteome. 28240269 2017
dbSNP: rs2237583
rs2237583
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C2257843
Disease:
paraoxonase activity 		0.700 GeneticVariation GWASDB Novel common and rare genetic determinants of paraoxonase activity: FTO, SERPINA12, and ITGAL. 23160181 2013
dbSNP: rs3917502
rs3917502
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0202236
Disease:
Triglycerides measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs3917510
rs3917510
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C1445957
Disease:
Serum total cholesterol measurement 		0.700 GeneticVariation GWASDB Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. 23063622 2012
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 GeneticVariation BEFREE This study will give an insight about the association of two selected candidate gene polymorphisms; paraoxonase1 (PON1) Q192R and apolipoprotein A5 (APOA5) -1131T>C were assessed in a cohort of South Indian patients having CAD with and without T2DM. 21438666 2011
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0011860
Disease:
Diabetes Mellitus, Non-Insulin-Dependent 		0.100 GeneticVariation BEFREE It has been hypothesized an A/B (Gln 192-->Arg) polymorphism of PON may be involved in the pathogenesis of CHD, especially among subjects with non-insulin-dependent diabetes mellitus (NIDDM). 8960946 1996
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C1956346
Disease:
Coronary Artery Disease 		0.100 GeneticVariation BEFREE The PON1-Q192R polymorphism had a profound impact on PON1-activity, but did not predict CAD risk (Odds Ratio [OR] per R allele 0.98[0.84-1.15], p = 0.8). 19710913 2009
dbSNP: rs662
rs662
Entrez Id: 5444
Gene Symbol: PON1
PON1
CUI: C0948008
Disease:
Ischemic stroke 		0.100 GeneticVariation BEFREE Taken together, our data indicate that the Q/R192 is principally associated with both CAD and ischemic stroke in Japanese. 10729395 2000